Designing Microfluidic Processes

We specialise in turning early-stage microfluidic ideas into robust, real-world-ready processes, from microfluidic chip design and feasibility testing to systems that support life science tool and instrument development. Not just experiments, but processes built for reproducibility, scalability and deployment.

Broad application expertise

from flow chemistry to 3D cell culture

Fully equipped microfluidic lab

ready to test, validate, and refine your idea

From proof to production

scaling concepts into real-world solutions

Micro and nanoparticle specialists

in design, synthesis, and testing

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Our diverse work

Our work spans microfluidic process development across assays, novel chemistries, particle engineering and flow-based systems. We help define what success looks like, then design, test and refine the process required to achieve it.

Particle and droplet generation

Flow chemistry & reaction engineering

Diverse polymer systems

Device/process prototyping and iteration

…and anything that doesn’t come with a manual.

From feasibility to refinement

Explore feasibility

We start at the bench - where your concept takes shape through hands-on microfluidic feasibility testing. Through rapid, hands-on experiments guided by our decades of experience, we explore what works, what doesn’t, and what your process needs to succeed. Every test moves us closer to a reliable, scalable solution.

Engineer the system

Once we’ve established the process, we start building around it. Our engineers design intuitive, modular systems tailored to your application, often evolving into custom microfluidic systems and platforms, pressure-driven workflows and integrated platforms - and we leverage our network of trusted fabrication partners to turn those designs into working prototypes.

Iterate. Improve

We solve microfluidic problems - the kind that don’t come with instructions. Whether you're validating a proof-of-concept or preparing for scale-up, we support the transition into real-world deployment and post-launch support. We stay close, test fast, and keep refining until everything works - cleanly, consistently, and at the level your science demands.

Shape the particle your application needs

We use microfluidic process control to develop particle systems with defined size, structure and material properties. Browse example formats and use them as a starting point for your own assay, delivery system or process development.

Browse the particle catalogue

Agarose beads in oil

Alginate beads in water

Agarose beads in water

Polystyrene microparticles

PMMA microparticles

PLGA curcumin microparticles

PLGA microparticles

Alginate beads in oil

Microfluidic tools for early process planning

Quick calculators for estimating flow, pressure drop, droplet output, residence time and production volume during early microfluidic system design.

Droplets in action

A look inside our microfluidic system at work

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Cross-disciplinary expertise

Biology, chemistry, microfluidics, and nanoparticle engineering - all under one roof. We don’t just understand the science, we engineer it into scalable systems.

A build-ready network

Need something made? We know who can build what, and how to make it happen fast. We engage fabrication partners we’ve worked with for years - so your prototypes don’t stay on paper.

Solutions for the unsolvable

Uncharted flows, complex assays, edge-case chemistries - we’ve handled the quirks and corner cases. When your process hits the "this-has-never-been-done" stage, we’re the team you want in the room.

With Blacksheep Sciences, you do not have to work through microfluidic uncertainty alone. We bring decades of lab work, product launches and real-world problem solving to help you test ideas faster, avoid costly missteps and move towards a process that is ready for use.

Frequently asked questions

Why should I consider a microfluidic approach?

Microfluidics is widely used in life science tools and medical devices due to its precise fluid control, reduced reagent use and cost, improved reaction times and throughput; and its ease of integration, automation and portability.

Can you help us design and make a new microfluidic chip?

We have some of the most experienced microfluidic engineers in the world. If it’s physically possible, our team can make it happen.

Do you have a preferred material or manufacturing method for microfluidics?

We are material agnostic. Different materials come with their own benefits and limitations, depending on your stage of product development. We choose the material that suits the requirements best, depending on cost, precision, speed and performance

Do you manufacture microfluidic chips?

We don’t manufacture microfluidic chips ourselves; we work with a world-class network of glass and polymer microfabrication partners. Our engineers can design for your needs while considering the right material and manufacturer to use. Whether it’s a prototype or a mass-produced single-use consumable, we know how to get it done.

I’m developing a new application using microfluidics, can you help?

Yes, we have a huge range of experience in developing and testing applications of microfluidics! Our scientists can help design and run the experiments you need.

Why make microparticles using microfluidics?

There are plenty of reasons to choose microfluidics over batch methods for microparticle production - low energy use, better process control, improved dispersity, and higher reproducibility, to name just a few.

What can you make micro and nano - particles out of?

At Blacksheep, we have extensive experience of using microfluidics to make microparticles out of polystyrene, polymethacrylate, polyacrylamide, alginate, agarose, poly-lactic-glycolic-acid (PLGA), polyacrylamide. We also have experience in making lipid, PLGA and other polymer nanoparticles.

Do you work with complex particles and emulsions?

We can produce Janus particles, core-shell structures, and double emulsions using microfluidic methods.

What if my idea works and I want to develop it into a product, platform or manufacturing process?

We’ve got a team of engineers with deep experience in life science instrument development. If your idea is viable, we can help you take it all the way to a working product or scalable process.

Is microfluidics compatible with living cells?

Absolutely - microfluidics can be used to generate spheroids and organoids and is one of the preferred methods for handling living cells in research and therapeutic development.

Can you manufacture custom microparticles?

Yes - our expertise allows us to produce highly monodisperse microparticles to your specified requirements.

Can you develop instruments that incorporate our microfluidics?

Yes - we can design and build instruments that integrate your microfluidic system as part of a complete platform.

What engineering expertise do you have?

Our team combines mechanical, electrical, and fluidic engineering with systems integration and life science instrumentation. We support a wide range of biotech and life science applications - including but not limited to microfluidic systems.

How much does a project cost?

Costs vary depending on the complexity and scope of your project. We offer flexible engagement models and can provide a quote once we understand your specific needs.

How long does a project take?

Timelines depend on the stage and scale of the project. Some take a few weeks, others several months. We’ll give you a clear timeline once we scope the work.